Leica DM4 B & DM6 B Biological Microscope

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Intelligent Automation for Life Science and Clinical Applications

Upright Microscopes Leica DM4 B & DM6 B

Increase your work efficiency with the Leica DM4 B or Leica DM6 B upright digital research microscopes! Both are ideally suited to making your work life easier in biomedical research and clinical labs alike.

  • Simplify your workflow with automated functions and easy-to-use software
  • Easily capture publication-quality images by utilizing the 19-mm sCMOS camera imaging port
  • Create fast overviews of your samples and identify the important details instantly with the LAS X Navigator Software
  • Have great flexibility through the choice of accessories such as Halogen or LED illumination
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See More in Less Time

Saving time in image acquisition means you have more time for what is really at the heart of your science. Here are just a few ways to speed up your workflow.

  • See up to 10.000x more of your sample with the LAS X Navigator. Set up high resolution image acquisition for slides, dishes and multiwell plates
  • Take full advantage of your sCMOS camera! The 19-mm field of view camera port perfectly fits the dimensions of common sCMOS sensors.
  • Make your slide examination faster at the highest resolution.
  • Choose the objective that best fits your application – from a range of more than 300 outstanding optics. Just one example: the unique 1.25x overview objective for a perfect wideview.

Free Your Mind!

Focus on the result you would like to achieve rather than the process of getting to it. Intelligent Automation does the work for you: It solves multi-step routines with the press of a button, makes your work life easier, saves time, and allows you to focus on your experiment, not on complex microscope settings.  

  • Change contrast with the push of a button – everything you need automatically slides into place.
  • Acquire publication-ready images using either Halogen or LED illumination
  • Use Light and Contrast Management to simplify your work – for example the Fluorescence Intensity Manager (FIM) and Excitation Manager (ExMan) for fluorescence images, or Koehler light management for perfect Koehler images.

Contrast method DIC

Unstained biological specimen often do not show a very high contrast.

Thick specimens in particular, such as brain slices, show up as nothing more than light grey structures instead of single cells.

Differential interference contrast

Differential interference contrast (DIC) is here an ideal contrast method.

(Image comparison: Neurons, 20x objective: N PLAN L 20x/0.35 DRY)

Differential interference contrast (DIC)

Exactly What You Need

You can configure the microscope that fits your need and budget with the Leica DM4 B and Leica DM6 B. Optimize your system to your application with different contrast methods, automated functions, or with the illumination you prefer. 

Halogen or LED illumination – that is the question!

  • LED illumination lights your sample homogenously and with a constant color temperature, while also saving energy and avoiding bulb changes due to the LED’s lifetime of up to 25,000 hours.
  • Halogen illumination does not naturally come with the constant color temperature that LEDs offer. But with the Leica DM6 B, the unique Constant Color Intensity Control (CCIC) maintains a constant color temperature of 3,200 K. 

Make Your Microscope an Imaging System

Leica Microsystems provides powerful cameras and workflow-based software to complete your integrated imaging system.  

  • Leica Application Suite X (LAS X) is our easy-to-use workflow-based software which guides you step by step to acquire the images you need.
  • Leica microscope cameras cover a broad range of applications from brightfield to fluorescence applications – or even one camera for multi-purposes both such as our Leica DFC7000 T camera

The Leica DM6 B Upright Microscope includes the Leica DFC7000 T Camera and LAS X Software.

Electrophysiology and Neurobiology with the Leica DM6 FS

If you need a microscope system to support you in neuroscience, evolutionary biology, or in vivo imaging, the Leica DM6 FS fixed stage widefield microscope should be your first choice. It is ideal for applications where you need to stimulate specimens from the outside like in optogenetics, or measure them in electrophysiological experiments such as patch clamp.

Your advantages in a nutshell

  • Vibration-free control ensures your sample is not disturbed.
  • All current-carrying elements are switched off if not in use, preventing sample disruption.
  • More clearance gives you easy access to samples.

Configured from the same stand as the Leica DM6 B, it is an outstanding tool for sophisticated experiments and also forms part of the Leica EM Cryo CLEM system.

Sample Preparation with Laser Microdissection

Facilitate sample preparation and achieve pure, contamination-free starting material for molecular biology analysis directly from a tissue section! Laser microdissection (LMD) helps you to isolate a precise region of interest, retaining cell morphology by separating your target cells from the rest of the sample. 

How do the Leica LMD systems work? 

  • The laser moves, not the sample. This is why the cuts are fast and clean.
  • Dissectates are collected via gravity directly into standard consumables, saving time and money.
  • Cut various preparations: fresh, frozen, fixed, or immuno-labeled samples, live cells, smear preparations, bone, plant, wood, dentin, and many more.